Is a rare disease that occurs when amyloid proteins are deposited in tissues and organs. Primary amyloidosis and dialysis-related amyloidosis are the types of amyloidosis that can affect the kidneys. The most common sign of primary amyloidosis of the kidneys is nephrotic syndrome. Your kidneys filter waste and toxins from your blood. Amyloid deposits in the kidneys make it hard for them to do this job. When your kidneys do not work properly, water and dangerous toxins build up in your body. If amyloidosis affects the kidneys, you may have: signs of kidney failure, including swelling of the feet and ankles and puffiness around the eyes, high levels of protein in your urine.